The Lowdown on Progesterone

[Anonymous]

1.) …
2.) “For those who wish bigger breasts, save your money, reduce the side effects and longer term risk and just eat more pies.” – !!!
3.) no citations?

well there are a couple of valid points mentioned in this pdf but over all I’m not too convinced.
I guess we all know that the information on TS HRT is to be taken with a grain of salt as it’s still quite new ground but this pdf seems to speak the opposite, and it is:-
1.) a lot better written
2.) contains sources
3.) and doesn’t induce laughter….
http://transmentors.org/resources/docs/HORMONE%20THERAPY,%20MALE-TO-FEMALE%20HRT.pdf

html version: http://74.125.155.132/scholar?q=cache:ltms4UrNjnQJ:scholar.google.com/&hl=en&as_sdt=2000

it also focuses on progesterone and has some interesting things to add.
Yet more info to add to the conflicting/confusing pile on HRT! lol!

[Anonymous]

Hi,
I did some research on pergesterone possibility and queried my gender doctor just reciently on what he had to say about it. Unfortunitely my research varified what he had to say.
Having read Sally’s link, I can only support the content of the article. It is a option I will be staying well clear of.

Pergesterone has effects on the milk sacks in the breasts by enlarging the sacks alone. The milk sacks are not uniform in the breast. By using pergesterone alone the breast line will be a distorted shape.

The best way someone can get breasts as quickly as possible is the conventional way.
Anti androgen and estrogen supplement.
I suggest not to take any of the phytoestrogens as they are weaker. Phytoestrogens will compete for the same receptiors as prognova for example, lessening the breast growth effects. Look at any other medical or natural food supplements that could compete for the same receptiors, as well

Jeorjette

Moderator

Quote:

WARNING
TrannyRadio is not a medical forum and any comments you may read in TR forums are only the opinions of the member posting. You should not assume that a posting on TR implies any verification or independent review and whilst the advice is honestly offered it is made without knowledge of your particular medical conditions. You should always seek professional medical advice before taking any action that might affect your health.

[Anonymous]

Having looked through that paper and read the part that says that progesterone doesn’t have any effect on breast growth I would believe. The only medication that I am on is an oestrogen one and I am seeing my breasts slowly grow. I think that this paper is worth a good read in general also.

Peta A.

[Anonymous]

Quote:

Hi,
….Pergesterone has effects on the milk sacks in the breasts by enlarging the sacks alone. The milk sacks are not uniform in the breast. By using pergesterone alone the breast line will be a distorted shape….

Jeorjette

Is this only in TS women or in CISwomen as well?
And when you say “progesterone alone” do you mean without AAs or oestrogen?
I’ve read that taking only AAs is bad news for your health and only taking oestrogen is also bad, they (AAs&oest.) need to be taken together together. Which to me makes sense but I get confused with what is right for TS-HRT and what is right for CIS-HRT. :S
I’ve read a lot of studies on HRT being done on CIS women and are just assumed to be the same for TS women.
S~

[Anonymous]

I have noticed a semi-huge split of opinion in the TS world when it comes to progestogens. Those that are for and those that are against.

I’d say those that are for are those that have actually used it and had benefits form doing so, and those that are against either have tried a particular brand that gave them a bad experience and made them no longer like P full stop. Or they had no effect or they read some negative info that they formulated an opinion from.

Some people say that we don’t have receptors for P hhmm then why do so many have both positive physical and mental signs of effect? hhmmm strange.

Some people say they don’t effect breast growth, which is also strange as real life experience and studies have proven otherwise..

http://i.imagehost.org/dl/62ffc73200b0c8890c9faaa10dc7827c/0609/Short_Term_and_Long_Term_Histologic_Effects_of_9.pdf

now this is for those that understand P and have dealt with GPs/doctors that actually understand it. This basically talks about the difference between bio-identical and synthetic.
I feel that the reason some doctors push the synthetic drugs is because they are patented by drug companies and the doctors act as unknowing marketing tools, they are told that synthetic is better when really it’s not, it’s just the way they were educated…. educated by a vested interest.
Synthetic are not bad bad they are just linked closer to side effects which is also why some doctors don’t prescribe P at all. Because all the studies are done while using the patented synthetic. Drug companies can’t patent something that is natural (or should I say bio-identical). By altering it they can patent it.

Not everyone shows side effects from progestins but the brands that have proven to be troublesome fall of the register from other favored brands. A lot of tests/studies are old and out of date. My endo hands me info that is dated from the 80-90s, interesting.
The difference between two common progestins; provera and duphaston is that provera can have an androgen effect if you are mega dosing. It doesn’t have a huge noticeable effect other than a more active libido.
Duphaston can not convert to T and has less side effects, it’s generally the preferred between the two.
Everyone is different as we all know by now so most can handle provera and swear by it’s results, while others have had bad reactions to it and will tell you to stay away from it.

In australia duphaston is the only progestogen that is covered for rebate. We can’t even get prometrium, which is the most popular bio-identical progesterone.. I was quite upset when I found this out. I can’t afford to import right now.
My endo repeatedly told me that because I was on androcur then I don’t need a progestogen and I almost believed him, until I asked my GP for a bloodtest of my P levels that came back mega low!!!! coincidence? Not really I wouldn’t be surprised if these so called antiandrogens with a weak progestogen action have zero effect on P levels, if it’s such a small amount it would just get destroyed in the gut? *shrugs* I’ll just go by my bloodtest results. My endo also said he doesn’t like to prescribe P because he doesn’t want to go to court. I found that hysterical personally.
so…
most commonly known to be safest of the bio-identical – prometrium
most commonly known to be safest of the synthetic – duphaston
from what I’ve researched…

For those that are against, I don’t understand why and I feel like anything to do with the internet you can find the answers you want to find. It comes down to which of the two sides seems more plausible from actual evidence. I can’t ignore the fact that I’ve heard many more actual TSs say they swear by it after taking it, than those saying stay away. And the fact that my current GP is just happens to be the most intelligent GP I’ve ever been to in my life, understands it and prescribes it (and no I don’t hold that opinion because we agree on a lot of issues, it’s because she really is that good).
But this is just my experience! ^__^

Moderator

Quote:

WARNING
TrannyRadio is not a medical forum and any comments you may read in TR forums are only the opinions of the member posting. You should not assume that a posting on TR implies any verification or independent review and whilst the advice is honestly offered it is made without knowledge of your particular medical conditions. You should always seek professional medical advice before taking any action that might affect your health.

[Anonymous]

I have been started on cyclic progesterone therapy. It is medroxyprogestrone 5 mg starting on day 14 of cycle and continuing until and including day 27 of the cycle. So far is seems to have a calming effect (easily dropping off to sleep at night). Not sure how I feel about it but for me it is better than antidepressants so far. It has been prescribed so I will keep yáll posted!

[Elizabeth]

I’m not on anything due to health reasons, however according to the article which I had not previously read perhaps one should consume more pies and fries for the desired outcome? But then natal girls gain the fat naturally without over eating pies and fries; you just can’t win.
Sounds a little like Hobson’s choice.
I guess the article is saying be content with what you have, or will have with medical intervention.

[Catherine]

Hi Ericka,

Good to hear the medication is providing some relief effect. You may wish to consider seeking other medical opinions, as the advise I got my from my Endo regarding cycling HT for MTF women, it is only effective if you are wishing to fall pregnant. That the only reason the female body cycles it’s hormone levels.

The best feminising results for MTF women, is to have a constant, effective supply of hormones; and in his opinion, that can be best provided through sub dermal implants.

You might feel fine during your 14-27 days, but what is the effect you experience during the 1-13 days. Perhaps may not do the condition you are on anti depressants for, much good.

That’s my experience and 2 cents worth. HT can be a dangerous process to play with. It can result in death, or least case serious damage to critical organs.

Huggs
Catherine

[Anonymous]

Hi Catherine,

Thanks for the advice, buts its not for feminizing. Two specialists and my GP, with input from the pharmacist came up with this regime. A long standing problem from my youth is the culprit. Not a problem when there is no oestrogen dominance.