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What makes Estrogen tick?
Hi,
Just something that is important for those who want to know moreI understant 80% of it
Extract
What Makes Estrogen Tick
“Estrogen receptors” are rarely talked about unless a woman is diagnosed with breast cancer (or a man with prostate cancer), but they are critical to how an estrogen behaves. For example, tamoxifen is a “known human carcinogen” due to its estrogenic effects, yet it is marketed as an “estrogen blocker” because of its estrogen-blocking effects. It has beneficial effects on bone, but negative effects on the circulatory system.1,2 It blocks estrogen-driven breast cancer growth temporarily, yet later becomes estrogenic in the same tissue, promoting new breast cancer. How can one “estrogen” do all these things?The answer is, partly, estrogen receptors, which are proteins in the body that react to estrogen. Estrogen is like fuel, and estrogen receptors are like machines. When fuel meets machine, things happen.
Unfortunately, what happens depends on which area of the body is in question. The receptors of different parts of the body are different. In other words, although all the machinery runs on some type of estrogen, not all the machinery does the same thing. Estrogen does different things in different parts of the body. It does one thing in the brain and another in the breast. It might surprise you to learn, for example, that the pituitary gland is second after the uterus as the most estrogen-responsive area of the body.3 So it is not accurate to think of estrogen as the thing that makes breast cancer cells grow.
Jeorjette